Clinical
Research - Radiation & NSCLC
Radiation
Therapy for Lung Cancer: Clinical Trial Review (Medscape)
Summarizes the results of clinical trials involving radiation
treatment for lung cancer presented at the 43rd annual meeting of the
American Society for Therapeutic Radiology and Oncology (ASTRO). Aimed
at physicians. Registration required for free access to Medscape. [2001]
Mortality
Risk From Radiation After Surgery for Lung Cancer (National
Cancer Institute)
Summary of a report published in The Lancet (7/98) that argues against
radiation therapy following surgery for early stage NSCLC.
Innovative
Treatment Strategies in Locally Advanced and/or Unresectable Non-small
Cell Lung Cancer (Moffitt Cancer Center)
by Benjamin Movsas, MD
7, no.1 Cancer Control (January/February 2000): 25-34
Reviews trials investigating innovative treatment strategies for patients
with locally advanced and/or unresectable NSCLC, including altered radiation
fractionation schema, conformal 3-dimensional radiotherapy, and combined
chemoradiotherapy regimens. [2/00]
Brachytherapy
Intraoperative
Brachytherapy Following Resection for High Risk Patients with Stage 1
NSCLC (ASCO Abstract)
Summarizes a study presented at ASCO 2001 that showed intraoperative
125 I brachytherapy following sublobar resection of Stage IA-IB NSCLC
in high risk patients is safe and preserves pulmonary function. Control
of local recurrence is superior to previously reported rates for sublobar
resections at intermediate follow-up. Notes that the advantage of intraoperative
brachytherapy is that it eliminates the need for time consuming adjuvant
external beam radiation. [5/01]
High-Dose-Rate Brachytherapy
Makes Palliative Radiation Effective Convenient for Lung Cancer Patients
(Doctor's Guide)
Discusses trial results reported at the 42nd Annual Meeting of the
American Society for Therapeutic Radiology (ASTRO) that found high-dose-rate
brachytherapy (HDR-BT) is an effective palliative therapy for central
lung tumors, and that afterloading of the bronchus with two applications
appears to be more effective and convenient for patients that is the standard
four application dose. [10/00]
Brachytherapy
& Lung Cancer - Recent MEDLINE Abstracts
Proton Beam Radiotherapy
Proton Therapy:
A Viable Treatment Option for Inoperable Lung Cancer (Doctor's
Guide)
Reports results of a clinical trial (published in the Fall 1999 CHEST)
showed proton beam radiotherapy compares favorably with traditional radiation
for treatment of inoperable, early stage NSCLC. With protons, local tumor
control was 87 percent, significantly higher that the average 50% control
rate achieved using traditional radiation. [4/00]
Proton
Beam Therapy - Recent MEDLINE Abstracts
Stereotactic Body Radiotherapy
Stereotactic
Radiosurgery for Lung Tumors: Preliminary Report of a Phase I Trial
(CTSNetJournals)
by Whyte, Richard I, et al.
75 Ann Thorac Surg (2003): 1097-1101
Abstract summarizes preliminary results of a Phase I trial of stereotactic
radiosurgery for the treatment of lung tumors found that single-fraction
radiosurgery is safe and feasible in selected cases. Additional studies
are planned to investigate the optimal radiation dose, best motion-suppression
technique, and overall treatment efficacy. [2003]
Stereotactic
Techniques - Recent MEDLINE Abstracts (PubMed)
Stereotactic
Techniques - Clinical Trials (ClinicalTrials.gov)
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